Creating and Validating a DNA Methylation-Based Proxy for Interleukin-6.

Anna J StevensonDanni A GaddRobert F HillaryDaniel L McCartneyArchie I CampbellRosie M WalkerKathryn L EvansSarah E HarrisTara L Spires-JonesAllan F McRaePeter M VisscherAndrew M McIntoshIan J DearyRiccardo E Marioni

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)

These results suggest methylation-based predictors can be used as proxies for inflammatory markers, potentially allowing for further insight into the relationship between inflammation and pertinent health outcomes.

Keyphrases

dna methylation
genome wide
oxidative stress
gene expression
copy number