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The relationship between ventilatory function and cognitive and behavioral impairment in ALS.

Jaimin S ShahOtto PedrazaEmir FesticBjörn E Oskarsson
Published in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2021)
Objective: To study the association between ventilatory function and cognitive and behavioral impairment in ALS patients accounting for the effects of pertinent covariates. Methods: Four hundred and eighty-one patients were identified from the Mayo Clinic Florida ALS registry who had concurrent forced vital capacity (FVC) and cognitive and behavioral testing using the ALS Cognitive Behavioral Screen (ALS-CBS). Multiple linear regression analysis was used to study the effects of FVC and relevant covariates on the ALS-CBS cognition score, subscores, and caregiver behavioral inventory. Results: FVC was positively correlated to the cognitive and behavioral subscores on the ALS-CBS (p < 0.001), and the correlation was independent of the effects of site of ALS onset, age, and years of education. Conclusion: Cognitive and behavioral function may be adversely affected by ventilatory impairment in ALS. The presence of cognitive and behavioral impairment warrants a detailed assessment of ventilatory function.
Keyphrases
  • amyotrophic lateral sclerosis
  • end stage renal disease
  • chronic kidney disease
  • primary care
  • prognostic factors
  • peritoneal dialysis
  • multiple sclerosis
  • radiation therapy
  • white matter
  • rectal cancer
  • patient reported