A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases.

Roberto Tadashi KodamaAlexandre Kazuo KuniyoshiCristiane Castilho Fernandes da SilvaDaniela Cajado-CarvalhoBruno DuzziDouglas Ceolin MarianoDaniel Carvalho PimentaRafael BorgesWilmar Dias da SilvaFernanda Calheta Vieira Portaro

Published in: The journal of venomous animals and toxins including tropical diseases (2020)

This work describes a Kunitz-type peptide toxin presenting inhibitory potential over serine and cysteine proteases, and this could contribute to further understand the envenomation process by D. polylepis. In addition, the PEP2 inhibits the cathepsin L activity with a low inhibition constant.

Keyphrases

escherichia coli
fluorescent probe
protein kinase
case report
human health
risk assessment