MMP-2 Associates With Incident Heart Failure and Atrial Fibrillation: The ARIC Study.
Leo F BuckleyAli M AghaPranav DorbalaBrian Lee ClaggettBing YuAliza HussainVijay NambiLin Yee ChenKunihiro MatsushitaRon C HoogeveenChristie M BallantyneAmil M ShahPublished in: Circulation. Heart failure (2023)
Higher plasma MMP-2 levels associate with diastolic dysfunction, left atrial dysfunction, and a higher risk of incident HF and AF. AF is a mediator of MMP-2-associated HF with preserved ejection fraction risk.
Keyphrases
- atrial fibrillation
- left atrial
- ejection fraction
- heart failure
- catheter ablation
- aortic stenosis
- left ventricular
- oral anticoagulants
- acute heart failure
- left atrial appendage
- cell migration
- direct oral anticoagulants
- cardiovascular disease
- oxidative stress
- percutaneous coronary intervention
- mitral valve
- blood pressure
- type diabetes
- cardiac resynchronization therapy