Polymethine-Based Semiconducting Polymer Dots with Narrow-Band Emission and Absorption/Emission Maxima at NIR-II for Bioimaging.
Ming-Ho LiuZhe ZhangYu-Chi YangYang-Hsiang ChanPublished in: Angewandte Chemie (International ed. in English) (2020)
Deep-penetration fluorescence imaging in the second near-infrared (NIR-II) window heralds a new era of clinical surgery, in which high-resolution vascular/lymphatic anatomy and detailed cancerous tissues can be visualized in real time. Described here is a series of polymethine-based semiconducting polymers with intrinsic emission maxima in the NIR-IIa (1300-1400 nm) window and absorption maxima ranging from 1082 to 1290 nm. These polymers were prepared as semiconducting polymer dots (Pdots) in aqueous solutions with fluorescence quantum yields of 0.05-0.18 %, and they demonstrate promising applications in noninvasive through-skull brain imaging in live mice with remarkable spatial resolution as well as signal-to-background contrast. This study offers a platform for future design of NIR-IIa or even NIR-IIb emitting Pdots.
Keyphrases
- fluorescence imaging
- fluorescent probe
- photodynamic therapy
- living cells
- high resolution
- drug release
- minimally invasive
- quantum dots
- magnetic resonance
- single molecule
- gene expression
- high throughput
- lymph node
- molecular dynamics
- coronary artery bypass
- computed tomography
- type diabetes
- molecularly imprinted
- solid state
- current status
- white matter
- skeletal muscle
- multiple sclerosis
- contrast enhanced
- resting state
- insulin resistance
- atrial fibrillation