Finite Element Modeling of Powder Compaction: Mini-Tablets in Comparison with Conventionally Sized Tablets.

Based on tablet size, small localized differences are noted (e.g., low-density regions, high shear bands, and heterogeneous density profiles), suggesting a possible risk of tableting defects for conventionally sized tablets compared to mini-tablets. Furthermore, it is observed that bevel-edged tablets could facilitate the formation of cracks, leading to possible capping failure.