Bark of Passiflora edulis Treatment Stimulates Antioxidant Capacity, and Reduces Dyslipidemia and Body Fat in db/db Mice.
Marielle Fernanda PanelliDamiana Tortolero PierineSérgio Luiz Borges de SouzaArtur Junio Togneri FerronJessica Leite GarciaKlinsmann Carolo Dos SantosMatheus Antônio Filiol BelinGiuseppina Pace Pereira LimaMilena Galhardo BorguiniIgor Otavio MinatelAntônio Carlos CicognaFabiane Valentini FrancisquetiCamila Renata CorrêaPublished in: Antioxidants (Basel, Switzerland) (2018)
Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation and oxidative stress as a trigger factor. Passiflora edulis contains important bioactive compounds, such as phenolics, carotenoids, vitamin C, and polyamines in pulp, leaves, seeds, and bark. Aim: To evaluate the effect of bark of Passiflora edulis (BPe) on body composition, and metabolic and oxidative stress parameters in genetically obese mice. Methods: Obese male db/db mice (n = 14 animals) received normal feeds and water ad libitum for 8 weeks. Then, animals were randomly divided to continue either receiving standard chow (obese, n = 7 (OB)) or feed with standard chow plus bark Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 8 more weeks, totaling 16 weeks. BPe was added to chow (7 g of BPe/kg of chow corresponding to 1.5 g/kg of body weight). The parameters evaluated in animals included food and caloric intake, body weight, body fat, plasma glucose, triglycerides, and total cholesterol. Malondialdehyde and antioxidant capacity were evaluated in plasma and organs. Groups were compared by Student t-test, with p < 0.05. Results: BPe reduced visceral and subcutaneous fat deposit and adiposity index, cholesterol and triglyceride levels, ameliorated the antioxidant capacity, and reduced malondialdehyde (MDA) levels. Conclusion: the bark of Passiflora edulis was effective in improving body composition, and metabolic and antioxidant parameters in obese mice.
Keyphrases
- body composition
- body weight
- oxidative stress
- adipose tissue
- weight loss
- insulin resistance
- metabolic syndrome
- resistance training
- high fat diet induced
- bone mineral density
- type diabetes
- arterial hypertension
- dna damage
- weight gain
- obese patients
- gestational age
- cardiovascular disease
- low density lipoprotein
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- risk assessment
- body mass index
- preterm birth
- postmenopausal women
- breast cancer cells
- wild type
- medical students
- heat shock