Integrated Stress Response Couples Mitochondrial Protein Translation With Oxidative Stress Control.
Guangyu ZhangXiaoding WangChao LiQinfeng LiYu A AnXiang LuoYingfeng DengThomas G GillettePhilipp E SchererZhao V WangPublished in: Circulation (2021)
These results suggest that the ISR improves cell survival and mitigates reperfusion damage by selectively suppressing mitochondrial protein synthesis and reducing oxidative stress in the heart.
Keyphrases
- oxidative stress
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- acute myocardial infarction
- heart failure
- signaling pathway
- cerebral ischemia
- atrial fibrillation
- acute ischemic stroke
- radiation induced
- radiation therapy
- binding protein
- left ventricular
- blood brain barrier
- subarachnoid hemorrhage