Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength.
Hirofumi AsanoAbdelazim Elsayed ElhelalyFuminori HyodoRyota IwasakiYoshifumi NodaHiroki KatoKoki IchihashiHiroyuki TomitaMasaharu MurataTakashi MoriMasayuki MatsuoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.
Keyphrases
- magnetic resonance imaging
- contrast enhanced
- locally advanced
- papillary thyroid
- high glucose
- early stage
- diabetic rats
- diffusion weighted imaging
- computed tomography
- gene expression
- squamous cell
- radiation therapy
- rectal cancer
- single cell
- drug induced
- radiation induced
- squamous cell carcinoma
- magnetic resonance
- oxidative stress