TGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13.

Jae-Young ParkHyun Cheol BaeSung Hee PyoMyung Chul LeeHyuk-Soo Han

Published in: Tissue engineering and regenerative medicine (2021)

TGFβ1 modulated catabolic processes in chondrocytes in a TG2-dependent manner. TGFβ1-induced TG2 might be the therapeutic target for treating cartilage degeneration and osteoarthritis.

Keyphrases

transforming growth factor
high glucose
diabetic rats
extracellular matrix
rheumatoid arthritis
drug induced
epithelial mesenchymal transition
signaling pathway
endothelial cells
oxidative stress