Diagnostic value of bone marrow core biopsy patterns in lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia and description of its mutational profiles by targeted NGS.

Julia Garcia-ReyeroNerea Martinez MagunacelayaSonia Gonzalez de VillambrosiaAngela Gomez MediavillaMarcela Urquieta LamAndres InsunzaRaul TondaSergi BeltranMarta GutAinara GonzalezSantiago Montes Moreno

Published in: Journal of clinical pathology (2020)

In conclusion, bone marrow core biopsy evaluation is critical in the identification of unequivocal bone marrow infiltration by LPL/WM. In addition to MYD88p.L265P, somatic mutations in CXCR4, KMT2D, PRDM1/Blimp1, MYC and ID3 can appear in a fraction of LPL/WM.

Keyphrases

bone marrow
mesenchymal stem cells
ultrasound guided
fine needle aspiration
transcription factor
toll like receptor
drug delivery