Immunoexpression of PD-L1, CD4+ and CD8+ cell infiltrates and tumor-infiltrating lymphocytes (TILs) in the microenvironment of actinic cheilitis and lower lip squamous cell carcinoma.
Vinícius Gonçalves de SouzaDamilys Joelly Souza SantosAna Gabriela SilvaRosy Iara Maciel de Azambuja RibeiroAdriano Mota LoyolaSérgio Vitorino CardosoCarla Silva Siqueira MirandaLudimila Paula Vaz CardosoPublished in: Journal of applied oral science : revista FOB (2022)
Therefore, the PD-L1 molecule may be a potential escape route for the immune response in oral lesions, but the mechanisms differ between AC and LLSCC. Future studies related to immune evasion and immunotherapy in oral lesions should consider the analysis of inflammatory infiltrate and TILs.