Initiation of ventricular arrhythmia in the acquired long QT syndrome.
C AlexanderMartin J BishopR J GilchristB A MResFrancis BurtonG L SmithRachel C MylesPublished in: Cardiovascular research (2022)
These data demonstrate that ICaL activation at sites displaying steep VGs generates the PVCs which induce TdP, providing a mechanism and rationale for LTCC blockers as a novel therapeutic approach in LQTS.