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TRIP13 Activates Glycolysis to Promote Cell Stemness and Strengthen Doxorubicin Resistance of Colorectal Cancer Cells.

Guangyi LiuHuan WangRui RanYicheng WangYang Li
Published in: Current medicinal chemistry (2024)
TRIP13 was highly expressed in CRC, which enhanced the DOX resistance of CRC cells by activating glycolysis to promote cell stemness. These findings offer new insights into the pathogenesis of DOX resistance in CRC and suggest that TRIP13 may be a new target for reversing DOX resistance in CRC.
Keyphrases
  • stem cells
  • single cell
  • induced apoptosis
  • epithelial mesenchymal transition
  • cell therapy
  • drug delivery
  • oxidative stress
  • cell cycle arrest
  • endoplasmic reticulum stress