AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.

Yameng SiJiadong HuangXiang LiYu FuRongyao XuYifei DuJie ChengHongbing Jiang

Published in: Cell communication and signaling : CCS (2020)

Our data demonstrate a previously unknown mechanistic linkage of AKT-mTOR/FOXO1 pathway between mutant ECs and SMCs in modulating venous dysmorphogenesis, and AKT/FOXO1 axis might be a potential therapeutic target for the recovery of TIE2-mutation causing VMs. Video Abstract.

Keyphrases

signaling pathway
pi k akt
cell proliferation
transcription factor
endothelial cells
electronic health record
wild type
machine learning
risk assessment
human health
human immunodeficiency virus
deep learning
high glucose
data analysis
antiretroviral therapy