Pharmacology of dipeptidyl peptidase-4 inhibitors and its use in the management of metabolic syndrome: a comprehensive review on drug repositioning.

Maryam RameshradBibi Marjan RazaviGordon A A FernsMahboobeh Ghasemzadeh Rahbardar

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2019)

The gathered data prove the efficacy of DPP-4 inhibitors in managing MetS in some levels beyond anti-diabetic effects. This review could be a lead for designing new DPP-4 inhibitors with greatest effects on MetS in future. Introducing drugs with polypharmacologic effects could increase the patient's compliance and decrease the health cost that there is not in multi-drug therapy. Graphical abstract ᅟ.

Keyphrases

metabolic syndrome
healthcare
public health
type diabetes
mental health
emergency department
drug induced
insulin resistance
cardiovascular disease
big data
health information
skeletal muscle
adipose tissue
machine learning
cell therapy
wound healing
replacement therapy
smoking cessation