Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice.
Y ShengY-J ChenZhong-Ming QianJ ZhengY LiuPublished in: Human & experimental toxicology (2020)
The reduced iron usage is one of the causes for iron overload in the liver and spleen and the increased tissue iron might be one of the mechanisms for CPX to induce oxidative stress and toxicities.