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Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function.

Meng-Chieh LinGuan-Yu ChenHsin-Hsien YuPei-Ling HsuChu-Wan LeeChih-Cheng ChengShih-Ying WuBo-Syong PanBor-Chyuan Su
Published in: Bone & joint research (2024)
Benzamil exerts anti-osteosarcoma activity by inducing apoptosis. In terms of mechanism, benzamil appears to inhibit integrin/FAK/STAT3 signalling, which triggers mitochondrial dysfunction and ATP depletion.
Keyphrases
  • cell migration
  • cell proliferation
  • oxidative stress
  • endoplasmic reticulum stress
  • cell adhesion
  • cell cycle arrest
  • cell death
  • heart failure
  • drug discovery