Repurposing the diuretic benzamil as an anti-osteosarcoma agent that acts by suppressing integrin/FAK/STAT3 signalling and compromising mitochondrial function.

Meng-Chieh Lin Guan-Yu Chen Hsin-Hsien Yu Pei-Ling Hsu Chu-Wan Lee Chih-Cheng Cheng Shih-Ying WuBo-Syong PanBor-Chyuan Su

Published in: Bone & joint research (2024)

Benzamil exerts anti-osteosarcoma activity by inducing apoptosis. In terms of mechanism, benzamil appears to inhibit integrin/FAK/STAT3 signalling, which triggers mitochondrial dysfunction and ATP depletion.

Keyphrases

cell migration
cell proliferation
oxidative stress
endoplasmic reticulum stress
cell adhesion
cell cycle arrest
cell death
heart failure
drug discovery