N6-methyladenosine reader hnRNPA2B1 recognizes and stabilizes NEAT1 to confer chemoresistance in gastric cancer.

Jiayao WangJiehao ZhangHao LiuLingnan MengXianchun GaoYihan ZhaoChen WangXiaoliang GaoAhui FanTianyu CaoDaiming FanXiaodi ZhaoYuanyuan Lu

Published in: Cancer communications (London, England) (2024)

Our findings indicated that hnRNPA2B1 interacts with and stabilizes lncRNA NEAT1, which contribute to the maintenance of stemness property via Wnt/β-catenin pathway and exacerbate chemoresistance in GC.

Keyphrases

stem cells
cancer stem cells
epithelial mesenchymal transition
cell proliferation
binding protein
long noncoding rna
mass spectrometry
high resolution