Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial-mesenchymal transition.
Mathew Suji EapenWenying LuTillie L HackettGurpreet Kaur SingheraMalik Q MahmoodAshutosh HardikarChris WardEugene Haydn WaltersSukhwinder Singh SohalPublished in: ERJ open research (2021)
This is the first systematic characterisation of small airway myofibroblasts in COPD based on their localisation, with statistically significant correlations between them and other pan-airway structural, lung function and ECM protein changes. Finally, we suggest that EMT may be involved in such changes.
Keyphrases
- lung function
- epithelial mesenchymal transition
- cystic fibrosis
- chronic obstructive pulmonary disease
- air pollution
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- transforming growth factor
- peritoneal dialysis
- smoking cessation
- patient reported
- risk assessment
- extracellular matrix
- protein protein