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Perfluoroalkylation of Thiosulfonates: Synthesis of Perfluoroalkyl Sulfides.

Ziwei LuoXinkan YangGavin Chit Tsui
Published in: Organic letters (2020)
A practical synthesis of perfluoroalkyl sulfides is described. The method employs stable and readily accessible thiosulfonates as new electrophiles with commercial nucleophilic perfluoroalkylating reagents. The mild reaction conditions allow access to a wide variety of both aryl- and alkyl-substituted perfluoroalkyl sulfides amenable to pharmaceutical development. Furthermore, the reaction operation is straightforward, odorless, does not produce toxic wastes, and, therefore should appeal to practitioners in industrial-scale productions.
Keyphrases
  • primary care
  • heavy metals
  • wastewater treatment
  • ionic liquid
  • risk assessment
  • electron transfer