Helicobacter pylori-induced modulation of the promoter methylation of Wnt antagonist genes in gastric carcinogenesis.

Hyo-Joon YangSang Gyun KimJoo Hyun LimJi Min ChoiWoo Ho KimHyun Chae Jung

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2017)

Epigenetic silencing of SFRP and DKK family genes may facilitate the formation of an epigenetic field during H. pylori-associated gastric carcinogenesis. The epigenetic field may not be reversed even after H. pylori eradication except by DKK3 methylation.

Keyphrases

dna methylation
genome wide
helicobacter pylori
helicobacter pylori infection
gene expression
stem cells
high glucose
diabetic rats
drug induced
endothelial cells
genome wide analysis