Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line.
Tianlong LiuTiejun ZhangFeng ZhouJitao WangXiaohu ZhaiNan MuJongsun ParkMinna LiuWenxing LiuPeijin ShangYi DingAidong WenYuwen LiPublished in: Cancer cell international (2017)
Our findings indicated that PHF20 is a pivotal upstream regulator. It affects the occurrence and development of glioma by regulating a series of tumor-related genes, such as FEN1, CCL3, PLCB1, NRAS and PIK3s, and activation of apoptosis signaling pathways. Therefore, PHF20 might be a novel biomarker for early diagnosis, and a potential target for glioblastoma therapies.
Keyphrases
- genome wide
- genome wide identification
- bioinformatics analysis
- signaling pathway
- oxidative stress
- endoplasmic reticulum stress
- risk assessment
- transcription factor
- cell cycle arrest
- copy number
- cell death
- genome wide analysis
- pi k akt
- liver injury
- dna methylation
- human health
- induced apoptosis
- gene expression
- epithelial mesenchymal transition
- drug induced