Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo.

Hongmei ZhuRichard L AutenAugustus Richard WhortonStanley Nicholas MasonCheryl B BockGary T KuceraZachary T KelleherAaron T VoseTimothy J McMahon

Published in: Thrombosis and haemostasis (2024)

This is the first study showing a role for SNO transport by LAT1 in ECs in a genetic mouse model. We provide the first direct evidence for the coordination of RBC SNO export with EC SNO import via LAT1. SNO flux via LAT1 modulates RBC-EC sequestration in lungs after transfusion, and its disruption impairs blood oxygenation by the lung.

Keyphrases

red blood cell
perovskite solar cells
reduced graphene oxide
room temperature
mouse model
cardiac surgery
gold nanoparticles
sickle cell disease
endothelial cells
genome wide
copy number