Structural phenotyping in atrial fibrillation with combined cardiac CT and atrial MRI: Identifying and differentiating individual structural remodelling types in AF.
Johanna B TonkoAngela LeeNilanka N MannakkaraSteven E WilliamsReza RazaviMartin J BishopMark O'NeillSteven NiedererJohn WhitakerPublished in: Journal of cardiovascular electrophysiology (2024)
AF is associated with significant quantifiable structural changes that are evident in LA size, tissue thickness, total LA tissue mass and fibrosis. These individual remodelling markers do not or only weakly correlate with each other suggesting different remodelling subtypes exist (e.g. fibrotic vs hypertrophic vs dilated). If confirmed, such a detailed understanding of the structural changes observed has the potential to inform clinical management strategies targeting individual mechanisms underlying the disease process.
Keyphrases
- atrial fibrillation
- contrast enhanced
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- magnetic resonance imaging
- direct oral anticoagulants
- heart failure
- computed tomography
- percutaneous coronary intervention
- left ventricular
- magnetic resonance
- cancer therapy
- high throughput
- idiopathic pulmonary fibrosis
- positron emission tomography
- acute coronary syndrome
- mitral valve