Plasma TDP-43 levels are associated with neuroimaging measures of brain structure in limbic regions.
Christopher E BauerValentinos ZachariouTiffany L SudduthLinda J Van EldikGregory A JichaPeter T NelsonDonna M WilcockBrian T GoldPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2023)
Plasma transactive response DNA binding protein of 43 kDa (TDP-43) levels were associated with entorhinal cortex volume.Biomarkers of TDP-43 and Alzheimer's disease neuropathologic change (ADNC) may help distinguish limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) from ADNC.A comprehensive biomarker kit could aid enrollment in LATE-NC clinical trials.