MicroRNA-34a-Dependent Attenuation of Angiogenesis in Right Ventricular Failure.
Sushma ReddyDong-Qing HuMingming ZhaoShoko IchimuraElizabeth A BarnesDavid N CornfieldMiguel A Alejandre AlcazarEdda SpiekerkoetterGiovanni FajardoDaniel BernsteinPublished in: Journal of the American Heart Association (2024)
In summary, miR-34a from fibroblasts, cardiomyocytes, and endothelial cells mediates capillary rarefaction by suppressing the hypoxia-inducible factor-1α-VEGF axis in RV hypertrophy/RVF, raising the potential for anti-miR-34a therapeutics in patients with at-risk RVs.