Correlation between circulating blood and microenvironment T lymphocytes in diffuse large B-cell lymphomas.
Filomena Emanuela LaddagaGiuseppe IngravalloAnna MesticeRoberto TammaTommasina PerroneEugenio MaioranoDomenico RibattiGiorgina SpecchiaFrancesco GaudioPublished in: Journal of clinical pathology (2021)
Overall, these data suggest that DLBCL with high TME T cells display a pre-existing antitumour immune response. In the rituximab-containing regimen, TME T cells are stimulated further to participate in the immune response against lymphoma cells. In contrast, DLBCL lymphomas with low T-cell infiltration reflect the absence of a pre-existing antitumour immunity and have a lower likelihood of obtaining an optimal response to therapy.
Keyphrases
- diffuse large b cell lymphoma
- immune response
- induced apoptosis
- cell cycle arrest
- dendritic cells
- stem cells
- toll like receptor
- magnetic resonance
- electronic health record
- endoplasmic reticulum stress
- big data
- oxidative stress
- cell death
- bone marrow
- inflammatory response
- chronic lymphocytic leukemia
- machine learning
- high grade
- pi k akt