Neuroprotective dobutamine treatment upregulates superoxide dismutase 3, anti-oxidant and survival genes and attenuates genes mediating inflammation.
Tina MarkusDavid LeyStefan R HanssonTadeusz WielochKarsten RuscherPublished in: BMC neuroscience (2018)
Neuroprotective treatment with dobutamine depresses expression of inflammatory mediators and promotes the defense against oxidative stress and depresses apoptotic genes in a model of neonatal brain hypoxia/ischemia interpreted as pharmacological preconditioning. We conclude that beta1-adrenoceptor activation might be an efficient strategy for identifying novel pharmacological targets for protection of the neonatal brain.
Keyphrases
- oxidative stress
- cerebral ischemia
- genome wide
- white matter
- resting state
- cell death
- bioinformatics analysis
- dna damage
- gene expression
- subarachnoid hemorrhage
- blood brain barrier
- multiple sclerosis
- endothelial cells
- dna methylation
- diabetic rats
- combination therapy
- replacement therapy
- heat stress
- heat shock
- free survival