Lercanidipine ameliorated doxorubicin-induced neuroinflammation and maintained the expressions of choline acetyltransferase via enhancing the levels of PI3K/AKT/HIF1-α expressions.
Melike D UnluSanem AsciHalil AsciSerife TasanOzlem OzmenRumeysa TanerSerpil DemirciPublished in: Molecular biology reports (2024)
Both LRD doses reversed all these findings, but LRD2 was observed to be more effective. In conclusion, we determined that LRD has potential therapeutic effect by reducing DOX-induced neuroinflammation, oxidative stress and apoptosis in brain tissues.
Keyphrases
- oxidative stress
- pi k akt
- diabetic rats
- cell cycle arrest
- signaling pathway
- high glucose
- traumatic brain injury
- cell proliferation
- lipopolysaccharide induced
- cerebral ischemia
- cell death
- lps induced
- endothelial cells
- cognitive impairment
- drug induced
- dna damage
- drug delivery
- endoplasmic reticulum stress
- white matter
- multiple sclerosis
- risk assessment
- brain injury
- resting state
- inflammatory response
- climate change
- subarachnoid hemorrhage