Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology.
Rasmus RydbirkOle ØstergaardJonas FolkeCasper HempelBrian DellaValleThomas L AndresenAnnemette LøkkegaardAnne-Mette HejlMatthias BodeMorten BlaabjergMette MøllerErik H DanielsenLisette SalvesenCharlotte C StarhofSara BechKristian WingeJørgen RungbyBente PakkenbergTomasz BrudekJesper V OlsenSusana AznarPublished in: Cellular and molecular life sciences : CMLS (2022)
Our results implicate activation of the fibrinolytic cascade and immune system in the brain as contributing factors in MSA associated with a more severe disease course.