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Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology.

Rasmus RydbirkOle ØstergaardJonas FolkeCasper HempelBrian DellaValleThomas L AndresenAnnemette LøkkegaardAnne-Mette HejlMatthias BodeMorten BlaabjergMette MøllerErik H DanielsenLisette SalvesenCharlotte C StarhofSara BechKristian WingeJørgen RungbyBente PakkenbergTomasz BrudekJesper V OlsenSusana Aznar
Published in: Cellular and molecular life sciences : CMLS (2022)
Our results implicate activation of the fibrinolytic cascade and immune system in the brain as contributing factors in MSA associated with a more severe disease course.
Keyphrases
  • resting state
  • white matter
  • functional connectivity
  • cerebral ischemia
  • subarachnoid hemorrhage