Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration.

Juan Ignacio Jiménez-LoygorriÁlvaro Viedma-PoyatosRaquel Gómez-SintesPatricia Boya

Published in: Molecular neurodegeneration (2024)

Collectively, these data highlight a novel putative application of UA in the treatment of AMD whereby it bypasses lysosomal defects by promoting p62-dependent lysophagy to sustain proteostasis.

Keyphrases

optical coherence tomography
electronic health record
respiratory failure
diabetic retinopathy
big data
aortic dissection
intensive care unit
combination therapy
machine learning
optic nerve
artificial intelligence
mechanical ventilation