A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes.

Leonard C HarrisonEsther Bandala-SanchezHelena OakeyPeter G ColmanKelly WatsonKi Wook KimRoy WuEmma E Hamilton-WilliamsNatalie L StoneAveni HaynesRebecca L ThomsonPeter J VuillerminGeorgia SoldatosWilliam D RawlinsonKelly J McGormGrant MorahanSimon C BarryRichard O SinnottJohn M WentworthJennifer J CouperMegan As Pennonull null

Published in: Journal of diabetes investigation (2023)

In a cohort of children at risk for type 1 diabetes followed from birth, a transient, systemic increase in mucosa-associated cytokines around the time of seroconversion lends support to the view that mucosal infection, e.g., by an enteric virus, may drive the development of islet autoimmunity.

Keyphrases

type diabetes
young adults
glycemic control
cardiovascular disease
ulcerative colitis
pregnant women
gestational age
subarachnoid hemorrhage
pregnancy outcomes