Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect.

Peng LuoChi ZhangFengying LiaoLong ChenZhenyu LiuLei LongZhongyong JiangYawei WangZiwen WangZujuan LiuHongming MiaoChunmeng Shi

Published in: Cell communication and signaling : CCS (2019)

Our study reveals for the first time that PC4 promotes breast cancer progression by directly regulating c-Myc transcription to promote Warburg effect, implying a novel therapeutic target for breast cancer.

Keyphrases

transcription factor
gene expression