Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic reticulum stress via enhancing autophagy in rats.
Yan PengLiyuan GuoAnxin GuBeibei ShiYukun RenJing CongXinming YangPublished in: Molecular medicine (Cambridge, Mass.) (2020)
Taken together, our findings indicate that EA treatment ameliorates insulin resistance, mitochondrial dysfunction, and ER stress through enhancing autophagy in a PCOS-like rat model. Our study provides novel insight into the mechanisms underlying the treatment of EA in PCOS, which offers more theoretic foundation for its clinical application.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- endoplasmic reticulum stress
- induced apoptosis
- metabolic syndrome
- adipose tissue
- type diabetes
- high fat diet
- cell death
- skeletal muscle
- oxidative stress
- high fat diet induced
- blood brain barrier
- spinal cord injury
- weight loss
- brain injury
- neuropathic pain
- depressive symptoms
- spinal cord
- subarachnoid hemorrhage
- glycemic control
- replacement therapy