Repetitive nasal allergen challenge in allergic rhinitis: Priming and Th2-type inflammation but no evidence of remodelling.

Nara T OrbanMikila R JacobsonKayhan T Nouri-AriaStephen R DurhamAarif O Eifan

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

Novel repetitive nasal allergen challenge in participants with severe persistent seasonal allergic rhinitis resulted in tissue eosinophilia and increases in IL-5 but no structural changes. Our data support no link between robust Th2-inflammation and development of airway remodelling in AR.

Keyphrases

allergic rhinitis
oxidative stress
high frequency
chronic rhinosinusitis
electronic health record
big data
early onset