Afatinib Reverses EMT via Inhibiting CD44-Stat3 Axis to Promote Radiosensitivity in Nasopharyngeal Carcinoma.

Huichao HuangFangling HuangXujun LiangYing FuZhe ChengYan HuangZhuchu ChenYankun DuanYongheng Chen

Published in: Pharmaceuticals (Basel, Switzerland) (2022)

Collectively, this work identifies the molecular mechanism of afatinib as a radiation sensitizer, thus providing a potentially useful combination treatment and drug target for NPC radiosensitization. Our findings describe a new function of afatinib in radiosensitivity and cancer treatment.

Keyphrases

epidermal growth factor receptor
advanced non small cell lung cancer
epithelial mesenchymal transition
signaling pathway
genome wide
cell proliferation
emergency department
gene expression
radiation therapy
adverse drug
drug induced