Neuromedin U secreted by colorectal cancer cells promotes a tumour-supporting microenvironment.

Patrycja Przygodzka Kamila Soboska Ewelina Sochacka Marcin Pacholczyk Marcin Braun Hassan Kassassir Izabela Papiewska-Pająk Michal Kielbik Joanna Boncela

Published in: Cell communication and signaling : CCS (2022)

We propose that NMU is involved in the modulation and promotion of the pro-metastatic tumour microenvironment in CRC through the activation of cancer cells and other tumour niche cells, macrophages and endothelial cells. Video abstract.

Keyphrases

endothelial cells
stem cells
induced apoptosis
squamous cell carcinoma
small cell lung cancer
oxidative stress
cell proliferation
cell death
vascular endothelial growth factor