The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study.

Annie M ConstableJosie E PorterDanielle BengerDimitrios Vlachopoulos Alan Robert Barker Sarah A Moore Sonja SoininenEero A HaapalaKate WestgateSoren BrageRicardo R AgostineteRomulo A FernandesTimo A Lakka

Published in: International journal of environmental research and public health (2021)

Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

Keyphrases

physical activity
young adults
body mass index
type diabetes
adipose tissue
bone mineral density
high intensity
drug induced