Effects of motor cortical and peripheral axonal hyperexcitability on survival in amyotrophic lateral sclerosis.

Ryo Otani Kazumoto Shibuya Yo-Ichi Suzuki Tomoki SuichiMarie MorookaYuya AotsukaMoeko OgushiSatoshi Kuwabara

Published in: Journal of neurology, neurosurgery, and psychiatry (2024)

In patients with ALS, both motor cortical and peripheral hyperexcitability independently affected survival time, with peripheral hyperexcitability having a greater impact on shorter survival. The modulation of neuronal/axonal excitability is a potential therapeutic target for ALS.

Keyphrases

spinal cord injury
free survival
chemotherapy induced
amyotrophic lateral sclerosis
risk assessment
working memory