Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.

Jun ShirakawaKazuki TajimaTomoko OkuyamaMayu KyoharaYu TogashiDario F De JesusGiorgio BasileTatsuya KinA M James ShapiroRohit N KulkarniYasuo Terauchi

Published in: Diabetologia (2020)

These results suggest that luseogliflozin can increase beta cell proliferation through the activation of the FoxM1/PLK1/CENP-A pathway via humoral factors that act in an insulin/IGF-1 receptor-independent manner.

Keyphrases

cell proliferation
immune response
type diabetes
binding protein
pi k akt
cell cycle
glycemic control
adipose tissue