Landscape of pharmacogenetic variants associated with non-insulin antidiabetic drugs in the Indian population.

Ambily SivadasS SahanaBani JollyRahul C BhoyarAbhinav JainDisha SharmaMohamed ImranVigneshwar SenthivelMohit Kumar DivakarAnushree MishraArpita MukhopadhyayGreg GibsonK M Venkat NarayanSridhar SivasubbuVinod ScariaAnura V Kurpad

Published in: BMJ open diabetes research & care (2024)

Indians and South Asians have a distinct PGx profile for antidiabetes drugs, marked by an excess of poor treatment response-associated alleles for various NIAD classes. This suggests the possibility of a population-specific reduced drug response in atleast some NIADs. In addition, our findings provide an actionable resource for accelerating future diabetes PGx studies in Indians and South Asians and reconsidering NIAD dosing guidelines to ensure maximum efficacy and safety in the population.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
clinical practice
drug induced
gene expression
metabolic syndrome
current status
adipose tissue
insulin resistance
adverse drug
genome wide