Transitions in oral and gut microbiome of HPV+ oropharyngeal squamous cell carcinoma following definitive chemoradiotherapy (ROMA LA-OPSCC study).
Marc OlivaPierre H H SchneebergerVictor ReyMatthew ChoRachel TaylorAaron R HansenKirsty TaylorAli HosniAndrew BayleyAndrew J HopeScott V BratmanJolie RingashSimron SinghIlan WeinrebBayardo Perez-OrdoñezDouglas ChepehaJohn WaldronWei XuDavid GuttmanLillian L SiuBryan CoburnAnna SpreaficoPublished in: British journal of cancer (2021)
Baseline oral and gut microbiomes differ by stage in this HPV+ cohort. CRT caused a shift towards a gut-like microbiome composition in oropharyngeal swabs. Stage-specific features and the transitions in oral microbiome might have prognostic and therapeutic implications.