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Transitions in oral and gut microbiome of HPV+ oropharyngeal squamous cell carcinoma following definitive chemoradiotherapy (ROMA LA-OPSCC study).

Marc OlivaPierre H H SchneebergerVictor ReyMatthew ChoRachel TaylorAaron R HansenKirsty TaylorAli HosniAndrew BayleyAndrew J HopeScott V BratmanJolie RingashSimron SinghIlan WeinrebBayardo Perez-OrdoñezDouglas ChepehaJohn WaldronWei XuDavid GuttmanLillian L SiuBryan CoburnAnna Spreafico
Published in: British journal of cancer (2021)
Baseline oral and gut microbiomes differ by stage in this HPV+ cohort. CRT caused a shift towards a gut-like microbiome composition in oropharyngeal swabs. Stage-specific features and the transitions in oral microbiome might have prognostic and therapeutic implications.
Keyphrases
  • squamous cell carcinoma
  • locally advanced
  • high grade
  • rectal cancer
  • atrial fibrillation
  • lymph node metastasis