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Prediction of Lymph Node Metastasis in Breast Cancer by Gene Expression and Clinicopathological Models: Development and Validation within a Population-Based Cohort.

Looket DihgeJohan Vallon-ChristerssonCecilia HegardtLao H SaalJari HäkkinenChrister LarssonAnna EhingerNiklas LomanMartin MalmbergPär-Ola BendahlÅke BorgJohan StaafLisa Rydén
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Although CLINICAL and MIXED predictors of nodal metastasis had comparable accuracy, the MIXED predictor identified more node-negative patients. This translational approach holds promise for development of classifiers to reduce the rates of SLNB for patients at low risk of nodal involvement.
Keyphrases
  • gene expression
  • lymph node metastasis
  • ejection fraction
  • newly diagnosed
  • lymph node
  • prognostic factors
  • dna methylation
  • neoadjuvant chemotherapy
  • radiation therapy
  • rectal cancer