Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.

Emily M RabjohnsKatlyn HurstArin GhoshMaria C CuellarRishi R RampersadTeresa K Tarrant

Published in: Current allergy and asthma reports (2021)

Recent studies have identified several variants in SQSTM1, OPTN, and other genes that may predispose individuals to Paget's disease of bone; studies of these genes and their protein products have elucidated new roles for these proteins in bone physiology. Understanding the pathologic mechanisms in the Pagetic osteoclast may lead to the identification of future treatment targets for other inflammatory and autoimmune diseases characterized by abnormal bone erosion and/or osteoclast activation.

Keyphrases

bone loss
bone mineral density
soft tissue
bone regeneration
genome wide
postmenopausal women
neoadjuvant chemotherapy
gene expression
copy number
lymph node
case control
locally advanced
genome wide identification
rectal cancer