BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma.

Xiao-Peng TianJun CaiShu-Yun MaYu FangHui-Qiang HuangTong-Yu LinHui-Lan RaoMei LiZhong-Jun XiaTie-Bang KangDan XieQing-Qing Cai

Published in: Cancer communications (London, England) (2020)

Our data showed that BRD2 promotes drug resistance in adult T-LBL through the RasGRP1/Ras/ERK signaling pathway. Targeting BRD2 may be a novel strategy to improve the therapeutic efficacy and prolong survival of adults with T-LBL.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition

wild type
diffuse large b cell lymphoma
electronic health record
cancer therapy

big data
childhood cancer
machine learning

drug delivery
oxidative stress
endoplasmic reticulum stress