Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study.

Sonja N TangVerena ZuberKonstantinos K Tsilidis

Published in: BMC medicine (2022)

Our findings support a likely causal role of genetically predicted levels of testosterone, HDL cholesterol, and IGF-1, as well as a novel potential role of ALP in breast cancer aetiology. Further studies are needed to understand full disease pathways that may inform breast cancer prevention.

Keyphrases

risk assessment
signaling pathway
replacement therapy
cell proliferation
climate change
binding protein
pi k akt
human health