Plasma Lipidomics Approach in Early and Specific Alzheimer's Disease Diagnosis.
Carmen Peña-BautistaLourdes Álvarez-SánchezMarta Isabel Roca-MarugánLorena García-VallésMiguel BaqueroConsuelo Cháfer-PericásPublished in: Journal of clinical medicine (2022)
The different plasma lipid profiles could be useful in the early and minimally invasive detection of AD. Among the lipid families, relevant results were obtained from DGs, LPEs, LPCs, MGs, and SMs. Specifically, MGs could be potentially useful in AD detection; while LPEs, LPCs, and SM seem to be more related to the preclinical stage, while DGs are more related to the MCI stage. Specifically, 18:1 LPE showed a potential utility as an AD biomarker.