Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts.
Karri SilventoinenWeilong LiAline JelenkovicReijo SundYoshie YokoyamaSari AaltonenMaarit PiirtolaMasumi SugawaraMami TanakaSatoko MatsumotoLaura A BakerCatherine TuvbladPer TyneliusFinn RasmussenJeffrey M CraigRichard SafferyGonneke WillemsenMeike BartelsCatharina E M van BeijsterveldtNicholas G MartinSarah E MedlandGrant W MontgomeryPaul LichtensteinRobert F KruegerMatt McGueShandell PahlenKaare ChristensenAxel SkyttheKirsten O KyvikKimberly J SaudinoLise DuboisMichel BoivinMara BrendgenGinette DionneFrank VitaroVilhelmina UllemarCatarina AlmqvistPatrik K E MagnussonRobin P CorleyBrooke M HuibregtseAriel Knafo-NoamDavid MankutaLior AbramsonClaire M A HaworthRobert PlominMorten Bjerregaard-AndersenHenning Beck-NielsenMorten SodemannGlen E DuncanDedra BuchwaldS Alexandra BurtKelly L KlumpClare H LlewellynAbigail FisherDorret I BoomsmaThorkild I A SørensenJaakko A KaprioPublished in: International journal of obesity (2005) (2022)
Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity.