Cascade aryne insertion/vinylogous aldol reaction of vinyl-substituted β-keto/enol carbonyls.

Nandikolla Krishna ChaitanyaY N Sambasiva RaoVenkata Surya Kumar Choutipalli Prathama S Mainkar Venkatesan Subramanian Srivari Chandrasekhar

Published in: Chemical communications (Cambridge, England) (2022)

Cyclic and acyclic vinyl substituted β-keto/enol carbonyl substrates, on reaction with arynes, result in differentially substituted naphthyl carbocycles, hitherto difficult to synthesize with existing protocols. While the substitutions on the arynes have no role, the ring size of the cyclic β-keto/enol esters has a profound influence on the product formation.

Keyphrases

molecular docking
intellectual disability
molecular dynamics simulations
electron transfer